1. Ayala, A.V., Hsu, C.Y., Oles, R.E., Matsuo, K., Loomis, L.R., Buzun, E., Terrazas, M.C., Gerner, R., Lu, H.H., Kim, S., Zhang, Z., Park, J.H., Rivaud, P., Thomson, M., Lu, L.F., Min, B., and Chu H. 2024. Commensal bacteria promote type I interferon signaling to maintain immune tolerance. J Exp Med.221(1):e20230063.

2. Lin, C.H., Wu, C.J., Cho, S., Patkar, R., Huth, W.J., Lin, L.L., Chen, M.C., Israelsson, E., Betts, J., Niedzielska, M., Patel, S.A., Duong, H.G., Gerner, R.R., Hsu, C.Y., Catley, M., Maciewicz, R.A., Chu, H., Raffatellu, M., Chang, J.T. and Lu, L.F. 2023. Selective IL-27 production by intestinal regulatory T cells permits gut-specific regulation of Th17 immunity. Nat Immunol. 24(12):2108-2120.

3. Chandra, S., Ascui, G., Riffelmacher, T., Chawla, A., Ramírez-Suástegui, C., Castelan, V.C., Seumois, G., Simon, H., Murray, M.P., Seo, G.Y., Premlal, A.L.R., Schmiedel, B., Verstichel, G., Li, Y., Lin, C.H., Greenbaum, J., Lamberti, J., Murthy, R., Nigro, J., Cheroutre, H., Ottensmeier, C.H., Hedrick, S.M., Lu, L.F., Vijayanand, P., and Kronenberg, M. 2023. Transcriptomes and metabolism define mouse and human MAIT cell populations. Sci Immunol. 8(89):eabn8531.

4. Dong, J., Huth, W.J., Marcel, N., Zhang, Z., Lin, L.L. and Lu, L.F. 2023. miR-15/16 clusters restrict effector Treg cell differentiation and function. J Exp Med. 220(10): e20230321.

5. Lin, C.H. and Lu, L.F. 2022. Fueling the fire in the gut. J Exp Med. 219(7): e20220723.

6. Lin, C.H., Chen, M.C., Lin, L.L., Christian, D.A., Min, B., Hunter, C.A. and Lu, L.F. 2021. Gut epithelial IL-27 confers intestinal immunity through the induction of intraepithelial lymphocytes. J Exp Med. 218(11): e20210021.

7. Cho, S.*, Dong, J.* and Lu, L.F. (*these authors contributed equally) 2021. Cell-intrinsic and -extrinsic roles of miRNAs in regulating T cell immunity. Immunol Rev. 304(1):126-140.

8. Zhou, X.* and Lu, L.F.* (*these authors contributed equally) 2021. Editorial: Regulators of a Regulator: Post-Transcriptional Regulation in Tregs. Front Immunol. 12:699911.

9. Sorrentino, C.*, Ciummo, S.*, D’Antonio, L., Lanuti, P., Abrams, S.I., Yin, Z., Lu, L.F. and Di Carlo, E. (*these authors contributed equally) 2021. Hindering triple negative breast cancer progression by targeting endogenous interleukin‐30 requires IFNgsignaling. Clin Transl Med. 11(2): e278.

10. Dong, J.*, Warner, L.M.*, Lin, L.L., Chen, M.C., O’Connell, R.M. and Lu, L.F. (*these authors contributed equally) 2021. MiR-155 promotes Treg cell development by safeguarding medullary thymic epithelial cell maturation. J Exp Med. 218(2): e20192423.

11. Boland, B.S., He, Z., Tsai, M.S., Olvera, J.G., Omilusik, K.D., Duong, H.G., Kim, E.S., Limary, A.E., Jin, W., Milner, J.J., Yu, B., Patel, S.A., Louis, T.L., Tysl, T., Kurd, N.S., Bortnick, A., Quezada, L.K., Kanbar, J.N., Miralles, A., Huylebroeck, D., Valasek, M.A., Dulai, P.S., Singh, S., Lu, L.F., Bui, J.D., Murre, C., Sandborn, W.J., Goldrath, A.W., Yeo, G.W. and Chang, J.T. 2020. Heterogeneity and clonal relationships of adaptive immune cells in ulcerative colitis revealed by single-cell analyses. Sci Immunol. 5(50): eabb4432.

12. Park, S., Shi, Y., Kim, B.C., Jo, M.H., Cruz, L.O., Gou, Z., Ha, T., Lu, L.F., Reich, D.H. and Chen, Y. 2020. Force-dependent trans-endocytosis by breast cancer cells depletes costimulatory receptor CD80 and attenuates T cell activation. Biosens Bioelectron. 165: 112389

13. Cho, S.*, Tai, J.W.* and Lu, L.F. (*these authors contributed equally) 2020. MicroRNAs and Their Targetomes in Tumor-Immune Communication. Cancers 12(8): E2025

14. Wu, C.J., Cho, S., Huang, H.Y., Lu, C.H., Russ, J., Cruz, L.O., da Cunha, F.F., Chen, M.C., Lin, L.L., Warner, L.M., Liao, H.K., Utzschneider, D.T., Quon, S., Berner, J., Camara, N.O.S., Zehn, D., Izpisua Belmonte, J.C., Chen, L.C., Huang, S.F., Kuo, M.L. and Lu, L.F. 2019. MiR-23~27~24-mediated control of humoral immunity reveals a TOX-driven regulatory circuit in follicular helper T cell differentiation. Sci Adv. 5(12): eaaw1715. PMCID: PMC6905868

15. Zhao, Y., Lee, C.K., Lin, C.H., Gassen, R.B., Xu, X., Huang, Z., Xiao, C., Bonorino, C., Lu, L.F., Bui, J.D. and Hui, E. 2019. PD-L1:CD80 Cis-heterodimer triggers the co-stimulatory receptor CD28 while repressing the inhibitory PD-1 and CTLA-4 pathways. Immunity 51(6):1059-73

16. Dong, J., Tai, J.W. and Lu, L.F. 2019. MicroRNA-microbiota Interaction in Gut Homeostasis and Colorectal Cancer. Trends Cancer 5(11): 666-669.

17. Becher,B., Waisman, A. and Lu,L.F. 2019. Cre-lox: Target Sensitivity Matters. Immunity 51(4):595.

18. Xu, H., Ye, Q., Tong, Z., Sun, T., Hong, Z., Zhang, L., Bortnick, A., Cho, S., Beuzer, P., Axelrod, J., Hu, Q., Wang, M., Evans, S.M., Murre, C., Lu, L.F., Sun, S., Corbett, K.D. and Cang, H. 2019. Molecular organization of mammalian meiotic chromosome axis revealed by expansion STORM microscopy. Proc Natl Acad Sci U S A. 116(37):18423-28. PMCID: PMC6744910

19. Sorrentino, C., Yin, Z., Ciummo, S., Lanuti, P., Lu, L.F., Marchisio, M., Bellone, M and Di Carlo, E. 2019. Targeting Interleukin(IL)-30/IL-27p28 signaling in Cancer Stem-like cells and Host Environment Synergistically Inhibits Prostate Cancer Growth and Improves Survival. J Immunother Cancer. 7(1):201. PMCID: PMC6670138

20. Yang, B.H., Wang, K., Wan, S., Liang, Y., Yuan, X., Dong, Y., Cho, S., Xu, W., Jepsen, K., Feng, G.S., Lu, L.F., Xue, H.H. and Fu, W. 2019. TCF1 and LEF1 Control Treg Competitive Survival and Tfr Development to Prevent Autoimmune Diseases. Cell Rep. 27(12):3629-45.

21. Seo, H., Chen, C., Avalos, E.G., Castruita, D.S., Das, A., Wang, Y.H., Lopez Moyado, I.F., Georges, R., Zhang, W., Onodera, A., Wu, C.J., Lu, L.F., Hogan, P.G., Bhandoola, A. and Rao, A. 2019. TOX and TOX2 cooperate with NR4A transcription factors to impose CD8+ T cell exhaustion. Proc Natl Acad Sci U S A. 116(25):12410-5.

22. Wen, L., Xin, B., Wu, P., Lin, C.H., Peng, C., Wang, G., Lee, J., Lu, L.F. and Feng, G.S. 2019. An Efficient Combination Immunotherapy for Primary Liver Cancer by Harmonized Activation of Innate and Adaptive Immunity. Hepatology. 69(6):2518-32.

1. Cho, S.*, Lee, H.M.*, Yu, I.S., Choi, Y.S., Huang, H.Y., Hashemifar, S.S., Lin, L.L., Chen, M.C., Afanasiev, N.D., Khan, A.A., Lin, S.W., Rudensky, A.Y., Crotty, S. and Lu, L.F. (*these authors contributed equally) 2018. Differential cell-intrinsic regulations of germinal center B and T cells by miR-146a and miR-146b. Nat Commun. 9(1):2757. PMCID: PMC6048122

2. Klann, J.E., Kim, S.H., Remedios, K.A., He, Z., Metz, P.J., Lopez, J., Tysl, T., Olvera, J.G., Ablack, J.N., Cantor, J.M., Boland, B.S., Yeo, G., Zheng, Y., Lu, L.F., Bui, J.D., Ginsberg, M.H., Petrich, B.G. and Chang, J,T. 2018. Integrin Activation Controls Regulatory T Cell-Mediated Peripheral Tolerance. J Immunol. 200(12):4012-23. PMCID: PMC5988969

3. Becher, B., Waisman, A. and Lu, L.F. 2018. Conditional Gene-Targeting in Mice: Problems and Solutions. Immunity 48(5):835-836.

4. Liao, H.K., Hatanaka, F., Araoka, T., Reddy, P., Wu, M.Z., Sui, Y., Yamauchi, T., Sakurai, M., O’Keefe, D., Nuñez, E., Guillen, P., Campistol, J.M., Wu, C.J., Lu, L.F., Esteban, C.R. and Izpisua Belmonte, J.C. 2017. In vivo target gene activation via CRISPR/Cas9-mediated trans-epigenetic modulation. Cell 171(7):1495-1507. PMCID: PMC5732045

5. Mann, M., Mehta, A., Zhao, J.L., Lee, K., Marinov, G.K., Garcia-Flores, Y., Lu, L.F., Rudensky, A.Y. and Baltimore D. 2017. An NF-kB-microRNA regulatory network tunes macrophage inflammatory responses. Nat Commun. 8(1):851. PMCID: PMC5636846

6. Wu, M.Z., Cheng, W.C., Chen, S.F., Nieh, S., O’Connor, C., Liu, C.L., Tsai, W.W., Wu, C.J., Martin, L., Lin, Y.S., Wu, K.J., Lu, L.F. and Izpisua Belmonte, J.C. 2017. miR-25/93 mediates hypoxia-induced immunosuppression by repressing cGAS. Nat Cell Biol. 19(10):1286-96. PMCID: PMC5658024

7. Wu, C.J. and Lu, L.F. 2017. MicroRNA in Immune Regulation. In: . Curr Top Microbiol Immunol. Springer, Berlin, Heidelberg

8. Cho, S., Wu, C.J., Nguyen, D.T., Lin, L.L., Chen, M.C., Khan, A.A., Yang, B.H., Fu, W., and Lu, L.F. 2017. A novel miR-24-TCF1 axis in modulating effector T cell responses. J Immunol. 198(10):3919-26. PMCID: PMC5437976

9. Glatman Zaretsky, A., Konradt, C., Dépis, F., Wing, J.B., Goenka, R., Atria, D.G., Silver, J.S., Cho, S., Wolfe, A.I., Quinn, W.J., Engiles, J.B., Brown, D.C., Beiting, D., Erikson, J., Allman, D., Cancro, M.P., Sakaguchi, S., Lu, L.F., Benoist, C.O. and Hunter, C.A. 2017. T Regulatory Cells Support Plasma Cell Populations in the Bone Marrow. Cell Rep. 18(8):1906-16. PMCID: PMC5361408

10. Cruz, L.O., Hashemifar, S.S., Wu, C.J., Cho, S., Nguyen, D.T., Lin, L.L., Khan, A.A. and Lu, L.F. 2017. Excessive expression of miR-27 impairs regulatory T cell-mediated immunological tolerance. J Clin Invest. 127(2):530-42. link

11. Liu, W.H., Kang, S.G., Huang, Z., Wu, C.J., Jin, H.Y., Maine, C.J., Liu, Y., Shepherd, J., Sabouri-Ghomi, M., Gonzalez-Martin, A., Xu, S., Hoffmann, A., Zheng, Y., Lu, L.F., Xiao, N., Fu, G. and Xiao, C. 2016. A miR-155-Peli1-c-Rel pathway controls the generation and function of T follicular helper cells. J Exp Med. 213(9):1901-19. link

12. Shaw, L.A., Bélanger, S., Omilusik, K.D., Cho, S., Scott-Browne, J.P., Nance, J.P., Goulding, J., Lasorella, A., Lu, L.F., Crotty, S. and Goldrath, A.W. 2016. Id2 reinforces TH1 differentiation and inhibits E2A to repress TFH differentiation. Nat Immunol. 17(7):834-43. link

13. Cho, S.*, Wu, C.J.*, Yasuda, T.*, Cruz, L.O., Khan, A.A., Lin, L.L., Nguyen, D.T., Miller, M., Lee, H.M., Kuo, M.L., Broide, D.H., Rajewsky, K., Rudensky, A.Y. and Lu, L.F. (*these authors contributed equally) 2016. MiR-23~27~24 clusters control effector T cell differentiation and function. J Exp Med. 213(2). link

14. Lu, L.F.*, Gasteiger, G.*, Yu, I.S., Chaudhry, A., Hsin, J.P., Lu, Y., Bos, P.D., Lin, L.L., Zawislak. C.L., Cho, S., Sun, J.C., Leslie, C.S., Lin, S.W. and Rudensky, A.Y. (*these authors contributed equally) 2015. A single miRNA-mRNA interaction affects the immune response in a context- and cell-type-specific manner. Immunity 43(1):52-64. link

15. Lee, H.M., Fleige, A., Forman, R., Cho, S., Khan, A.A., Lin, L.L., Nguyen, D.T., O’Hara-Hall, A., Yin, Z., Hunter, C.A., Muller, W. and Lu, L.F. 2015. IFNg signaling endows DCs with the capacity to control type I inflammation during parasitic infection through promoting T-bet⁺ regulatory T cells. PLoS Pathog. 11(2):e1004635. link

16. Miyazaki, M., Miyazaki, K., Chen, S., Itoi, M., Miller, M., Lu, L.F., Varki, N., Chang, A.N., Broide, D.H. and Murre, C. 2014. Id2 and Id3 maintain the regulatory T cell pool to suppress inflammatory disease. Nat Immunol. 15(8):767-76. link

17. Lee, H.M., Nguyen, D.T. and Lu, L.F. 2014. Progress and challenge of microRNA research in immunity. Front Genet. 5:178. PMCID: PMC4053854 link

18. Ho, B.C., Yu, I.S., Lu, L.F., Rudensky, A.Y., Chen, H.Y., Tsai, C.W., Chang, Y.L., Wu, C.T., Chang, L.Y., Shih, S.R., Lin, S.W., Lee, C.N., Yang, P.C. and Yu, S.L. 2014. Inhibition of miR-146a prevents enterovirus-induced death by restoring the production of type I interferon. Nat Commun. 24(5):3344. link

19. Pierson, W., Cauwe, B., Policheni, A., Schlenner, S.M., Franckaert, D., Berges, J., Humblet-Baron, S., Schönefeldt, S., Herold, M.J., Hildeman, D., Strasser, A., Bouillet, P., Lu, L.F., Matthys, P., Freitas, A.A., Luther, R.J., Weaver, C.T., Dooley, J., Gray, D.H., Liston, A. 2013. Antiapoptotic Mcl-1 is critical for the survival and niche-filling capacity of Foxp3+ regulatory T cells. Nat Immunol. 14(9):959-65. PMCID: PMC4128388 link

1. Josefowicz, S.Z.*, Lu, L.F.* and Rudensky, A.Y. (*these authors contributed equally) 2012. Regulatory T cells: mechanisms of differentiation and function. Annu Rev Immunol. 30:531-64. link

2. Wang, L., Rubinstein, R., Lines, J.L., Wasiuk, A., Ahonen, C., Guo, Y., Lu, L.F., Gondek, D., Wang, Y., Fava, R.A., Fiser, A., Almo, S. and Noelle, R.J. 2011. VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses. J Exp Med. 14;208(3): 577-92. PMCID: PMC3058578 link

3. Lu, L.F., Boldin, M.P., Chaudhry, A., Lin, L.L., Taganov, K.D., Hanada, T., Yoshimura, A., Baltimore, D. and Rudensky, A.Y. 2010. Function of miR-146a in controlling Treg cell-mediated regulation of Th1 responses. Cell 142(6): 914-29. PMCID: PMC3049116 link

4. Liston A., Linterman, M. and Lu, L.F. 2010. MicroRNA in the adaptive immune system, in sickness and in health. J Clin Immunol. 30(3):339-346. PMCID: PMC Journal – In Process link

5. Lu, L.F. and Liston A. 2009. MicroRNA in the immune system, microRNA as an immune system. Immunology 127(3): 291-298. PMCID: PMC2712098 link

6. Lu, L.F. and Rudensky A. 2009. Molecular orchestration of differentiation and function of regulatory T cells. Genes Dev. 23(11): 1270-1282. PMCID: PMC2763538 link

7. Lu, L.F.*, Thai, T.H.*, Calado, D.P.*, Chaudhry, A., Kubo, M., Tanaka, K., Loeb, G.B., Lee, H., Yoshimura, A., Rajewsy, K. and Rudensky, A.Y. (*these authors contributed equally) 2009. Foxp3-dependent microRNA155 confers competitive fitness to regulatory T cells through targeting SOCS1 protein. Immunity 30(1):80-91. PMCID:PMC2654249 link

8. Gondek, D.C., Devries, V, Nowak, E.C., Lu, L.F., Bennet. K.A., Scott, Z.A. and Noelle, R.J. 2008. Transplantation survival is maintained by granzyme b+ regulatory cells and adaptive regulatory T cells. J Immunol. 181 (7): 4752-4760. PMCID:PMC2572718 link

9. Liston, A.*, Lu, L.F.*, Carroll D.O., Tarakhovsky, A. and Rudensky, A.Y. (*these authors contributed equally) 2008. Dicer-dependent microRNA pathway safeguards regulatory T cell function. J Exp Med. 205(9):1993-2004. PMCID: PMC2526195 link

10. Lu, L.F., Gavin, M.A., Rasmussen, J.P. and Rudensky A.Y. 2007. G protein-coupled receptor 83 is dispensable for the development and function of regulatory T cells. Mol Cell Biol.27(23): 8065-8072. PMCID: PMC21691731. link

11. Lu, L.F.*, Ahonen, C.L.*, Lind, E.F., Raman V.S., Cook, W.J., Lin, L.L. and Noelle R.J. (*these authors contributed equally) 2007. The in vivo function of the alternative TRAF2 binding site on CD40-driven B cell growth and differentiation. Blood 110(1): 193-200. PMCID: PMC1896113 link

1. Lu, L.F., Lind, E.F., Gondek, D.C., Bennett, K.A., Gleeson, M.W., Pino-Lagos, K., Scott, Z.A., Coyle, A.J., Reed, J.L., Van Snick, J, Strom, T.B., Zheng, X.X. and Noelle R.J. 2006. Mast cells as essential intermediaries in regulatory T cell tolerance. Nature 442 (7106): 997-1002. link

2. Lu, L.F., Gondek, D.C., Scott, Z.A. and Noelle, R.J. 2005. NFkB-inducing kinase deficiency results in the development of a subset of regulatory T cells, which shows a hyperproliferative activity upon GITR stimulation. J Immunol. 175: 1651-1657. link

3. Gondek, D.C.*, Lu, L.F.*, Quezada, S.A., Sakaguchi, S. and Noelle, R.J. (* these authors contributed equally) 2005. Cutting Edge: Contact-mediated suppression by CD4+CD25+ regulatory cells involves a granzyme B-dependent, perforin-independent mechanism. J Immunol. 174:1783-1786. link

4. Liu, K.J., Lu, L.F., Cheng, H.T., Hung, Y.M., Shiou, S.R., Whang-Peng, J. and Juang, S.H. 2003. Concurrent delivery of tumor antigens and activation signals to dendritic cells by irradiated CD40 ligand-transfected tumor cells resulted in efficient activation of specific CD8+ T cells. Cancer Gene Ther. 1-13. link

5. Lu, L.F., Cook, W.J., Lin, L.L. and Noelle, R.J. 2003. CD40 signaling through a newly identified TRAF2 binding site. J Biol Chem. 278 (46): 45414-45418. link

1. Chang, Y.S., Lu, L.F., Lai, C.Y., Kou, Y.H. and Huang, F.L. 1999. Purification, characterization, and molecular cloning of an outer layer protein of carp fertilization envelope. Mol Reprod Dev. 54: 186-193. link